… in cancer treatment by natural products are MAPK, PI3K/Akt, and NF- κB [4], [5]. Notably, it has
been observed that signal transducer … Breast cancer, colorectal cancer, gastric cancer, and …

… signal transduction during tumorigenesis is still not fully understood. In fact, recent studies
from our laboratory showed that TNF-β signaling … and malignancy of colon cancer cells. …

… signaling is involved in regulating CRC cell proliferation as well. This research indicated that
signal transducers … and its down streams through PTEN/AKT signaling pathway [85]. The …

… studies has reduced the incidence of colon cancer in familial … advance cancer stages, and
are involved in cross talk with … NF-κB and signal transduction and activation of transcription (…

… STAT1 is one of the seven mammalian members of the signal transducer and activator of
the transcription (STAT) family. STAT1 plays an essential role in the immune response and …

… The major cause of colorectal cancer (CRC) related mortality is due to its metastasis. Signaling
… Lipid metabolism has an indispensable influence on Shh signal transduction. Lipids can …

… bivalent state and contributes to the maintenance of colorectal cancer-initiating cells [54,
56]… of DCs through the signal transducer and activator of transcription 3 (STAT3) signaling …

… both miRNAs and OS system were described in colorectal cancer (CRC), it is fundamental …
Additionally, phosphorylation of the signal transducer and activator of transcription 3 (STAT3) …

… These findings may improve our understanding of the cross-talk between m 6 A- and m 5
C-related lncRNAs in CRC and pave a new road for prognosis assessment and more effective …

… The PAM axis is the most frequently activated signaling pathway in human cancer … in cancer.
In this review we highlight the major dysregulations in the PAM signaling pathway in cancer, …